Ion Channel Studies
iPSC Sensory Neurons
Sygnature Discovery’s iPSC Electrophysiology Platform
Physiologically relevant DRG electrophysiology
Our platform captures the firing potential and functional maturity of sensory neurons, creating a dependable foundation for pain-focused discovery workflows.
As iPSC-derived DRG neurons mature in culture, they exhibit hallmark features of native nociceptors. Action potentials can be evoked and modulated, enabling functional validation of ion channel activity and assessment of pharmacological assets.
High-Throughput Electrophysiology
With the capacity to measure and modulate individual ion channel responses, our platform supports the generation of high-quality, pharmacological data from physiologically relevant cell systems.
Consistent expression of voltage-gated sodium channels is observed across a six-week maturation period, supporting reliable assay windows. The ability to generate concentration-response data across a range of pharmacological agents enables high-throughput screening applications.
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iPSC Sensory Neuron Case Study
Discovery how Sygnature Discovery uses iPSC-derived DRG neurons and automated electrophysiology to study ion channel activity in sensory neurons – advancing pain and sensory disorder research.
