An industry leader in specialist contract research, SB Drug Discovery’s is ready to support your lysosomal ion channel research, providing off-the-shelf, customized hit identification and lead optimization services for a broad range of lysosomal ion channel targets.
Introduction
TMEM175 is a novel, constitutively active ion channel involved in the regulation of lysosomal pH, lysosomal Δψ and autophagy. TMEM175’s significance lies not only in its physiological role but also in its therapeutic promise. Dysfunction of TMEM175 has been associated with lysosomal storage disorders and neurodegenerative diseases such as Parkinson’s and Alzheimer’s. As such, understanding TMEM175’s role in health and disease may provide opportunities for therapeutic interventions targeting these conditions. SB Drug Discovery stands at the forefront of TMEM175 research, offering an array of specialized services and cutting-edge capabilities to understand this target’s therapeutic potential.
Supporting Your Research
A lack of specific pharmacological tools has hampered detailed characterization of the role of TMEM175 in normal lysosomal function and related pathological processes.
SB Drug Discovery has developed an extensive catalogue of ion channel cell lines including a spectrum of TMEM175 reagents such as wild type and Loss/Gain of Function (LoF/ GoF) variants, alongside a variety of species orthologs.
