Discover how SB Drug Discovery’s multimodal assay system, featuring custom GFRAL/RET cell lines and SRE luciferase reporter assays, can drive your GDF15-GFRAL drug discovery. Utilizing both high-throughput screening and pERK ELISA platforms, SB Drug Discovery enables detailed monitoring of GDF15-induced signalling, ensuring robust, reproducible data.
Introduction
As a distant member of the transforming growth factor-beta (TGF-β) superfamily, Growth Differentiation Factor 15 (GDF15) functions through its receptor, Glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like (GFRAL). Recently, the GDF15-GFRAL-RET signalling complex has emerged as a focal point for research, with RET acting as a co-receptor for GFRAL and facilitating downstream signalling pathways.
Figure 1. Schematic representation of GDF15-GFRAL-RET complex signalling pathway.
This collaboration underscores the multifunctional nature of GDF15-GFRAL-RET, impacting pathways critical for cellular stress response and energy balance. Given its regulatory influence across broad physiological systems, this pathway presents new therapeutic opportunities, particularly in areas such as metabolic disorders and cancer.
