Cell Line Generation

Delivering Quality and Performance to your Drug Discovery Research

When it comes to the success of your drug discovery research, reagent quality and performance cannot be compromised. That’s why, at SB, we specialize in delivering premium, custom cell line generation solutions that provide a competitive advantage.

Years of Experience

Cell Lines Generated

Customer Projects

Utilising the latest technologies and innovative approaches, our team of leading scientists meticulously interrogates hundreds of individual cell clones at each stage of the cell line generation process, ensuring the highest quality reagents and target solutions for your research needs. Our extensive cell biology experience has enabled us to streamline our development processes to deliver rapid, cost-effective stable cell lines and assay systems. With over 20 years of experience, SB has the expertise and capabilities to meet your cell line generation needs.

Our Customizable Cell Line Generation Process

  • Precision Construct Design
    Optimal expression of your target of interest via custom-made expression constructs.

  • Antibiotic Selection Optimization
    Identifying the optimal selection concentration for your specific cell type.

  • Optimized Transfection
    Successfully introducing expression constructs into challenging cell types and validating target expression.

  • Clonal Isolation
    Identifying individual cell clones using limiting dilution and expansion under antibiotic selection.

  • Functional Profiling
    Thoroughly assessing functional attributes of isolated clones to identify the most fitting candidates.

  • Quality Check
    Comprehensive quality control criteria, ensuring expression stability and reliability.

  • Amplification and Stock Generation
    Expansion and preparation of stocks for future applications.

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Plasmid
Generation

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Functional
Validation

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Clone
Characterisation

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Functional
Assessment

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QC Process &
Stock Generation

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Stable Cell
Line Delivery

Our streamlined custom cell line generation process creates reliable and consistent stable cell reagents displaying robust expression of your desired target.

Efficient solutions for your research

Ion Channel Studies from SB Drug Discovery

ion channels

Our electrophysiology team provide a wealth of expertise to support the generation of recombinant ion channel cell lines. Through precise selection of reagents tailored to your specific ion channel interests, we facilitate the advancement of your ion channel research.

Receptor Pharmacology from SB Drug Discovery

Receptors

Using cutting-edge cell-based assay technologies to study biased signalling, we create robust receptor expressing cell lines to further your research. In addition, our experienced scientists develop optimized assays to investigate downstream signalling pathways.

Cell Line Generation - SB Drug Discovery

Specialized Cell Lines

Supplementing our expertise in ion channel and receptor cell line generation, our experience extends to generating recombinant cell lines expressing an array of membrane proteins, cytosolic proteins, and complex reporter systems.

Contact SB Drug Discovery

To learn more about our services or to request a quote.

Case Study

Development of a multimodal assay system for GDF15/GFRAL drug discovery.

Discover how SB Drug Discovery’s multimodal assay system, featuring custom GFRAL/RET cell lines and SRE luciferase reporter assays, can drive your GDF15-GFRAL drug discovery. 

Development of a multimodal assay system for GDF15/GFRAL drug discovery
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