Ion Channel Studies

GABAA Receptors

Ion Channels

Access the targets you need

Our comprehensive GABAA platform enables in-depth characterization of your receptor subtype of choice enabling rapid hit identification as well as detailed subtype selectivity assessment. Access our world-renowned GABAA expertise to fast-track your drug discovery research.

GABAA Subtypes
α1β1γ2 α4β1γ2
α1β2γ2 α4β2γ2
α1β3γ2 α4β3γ2
α2β1γ2 α5β1γ2
α2β2γ2 α5β2γ2
α2β3γ2 α5β3γ2
α3β1γ2 α6β1γ2
α3β2γ2 α6β2γ2
α3β3γ2 α6β3γ2
α4β3δ α6β3δ

Flexible assay formats

GABAA receptor assays can be run using fluorescence-based or electrophysiology platforms at a single concentration or in dose-response format, using a range of validated or customized protocols to help drive your research. Our flexible subtype selectivity panels are available to quickly assess compound potency across chosen subtypes, giving greater insight in to compound selectivity.

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GABAA Electrophysiology

Figure 1: Representative GABAα1β2γ2 current traces before (grey line) and during the presence of increasing concentrations of the agonist Diazepam (blue lines). Currents are obtained using a steady-state protocol at -80mV.

Figure 1: Representative GABAα1β2γ2 current traces before (grey line) and during the presence of increasing concentrations of the agonist Diazepam (blue lines). Currents are obtained using a steady-state protocol at -80mV.

Case Study

Subtype selective GABAA modulation

Discover how our comprehensive GABAA receptor expertise and data-driven insights can expedite your CNS drug discovery research today. 

View the case study
Subtype selective GABAAR modulation

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