Ion Channel Studies
Glycine Receptors
Flexible assay formats
Our customizable assays leverage fluorescence-based screening and advance electrophysiology techniques to enable robust hit identification and lead optimization campaigns. With our flexible approach, SB Drug Discovery adapts to your unique research requirements, delivering high-quality data with rapid turn-around times.
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Glycine Receptor Electrophysiology
Figure 1: Representative GlyRα3 current traces before (grey line) and during the presence of increasing concentrations of the potentiator Cannabidiol (blue lines). Currents are obtained using a steady-state protocol at -80mV.
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Services from SB Drug Discovery
Robust glycine receptor cell lines compatible with fluorescence-based assays and automated electrophysiology.
Representative current trace (left) and time course (right) for GlyRα3 positive modulator assay.
A range of validated agonist, antagonist and modulator assay formats are available to rapidly assess compound effect and rank potencies.
Representative current traces (left) and EC50 plot (right) for GlyRα3 positive modulator assay.
