Ion Channel Studies
NMDA Receptors
Flexible assay formats
Our glutamate receptor assays integrate high-quality recombinant cell lines with advanced automated patch clamp electrophysiology, delivering reliable and insightful data tailored for high-throughput screening and downstream evaluation of positive and negative modulators. The adaptable framework supports single or multi-mode assays, customizable protocols, and flexible parameters, allowing precise assessments of compound potency.
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Glutamate Receptor Electrophysiology
Figure 1: Representative GluN1/2A current traces before (grey line) and during the presence of increasing concentrations of the agonist Glutamate (in the presence of 100 µM Glycine) (blue lines). Currents are obtained using a steady-state protocol at -80mV.
Case Study
Automated electrophysiology screening of gain- and loss-of-function variants in the N-methyl-D-aspartate receptor GRIN gene family
