Ion Channel Studies
Other Channels
Flexible assay formats
SB Drug Discovery’s ion channel expertise spans high-throughput screening and lead optimization using a range of fluorescence-based assays and state-of-the-art electrophysiology platforms. Integrating the SURFE2R technology to measure lysosomal channel activity, our team offers an entire cascade of assay formats to support lysosomal channel drug discovery.
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TMEM175 Electrophysiology
Figure 1: Representative TMEM175 current traces before (grey line) and during the presence of increasing concentrations of the blocker 4-Aminopiridine (blue lines). Currents are evoked by a 500 ms ramp from -80 mV to +80 mV, followed by a 500 ms step from -80 mV to + 80 mV before returning to the holding potential of 0 mV.
TMEM175 screening assays
Validated high-throughput screening assay
Robust electrophysiology assays ready to run
Disease-relevant variant cell lines & assays
Range of species orthologs
Case Study
A Multi-Platform Approach to TMEM175 Drug Discovery
TMEM175 is a novel, constitutively active ion channel involved in the regulation of lysosomal pH, lysosomal Δψ and autophagy. TMEM175’s significance lies not only in its physiological role but also in its therapeutic promise.
