Ion Channel Studies

Potassium Channels

Access the targets you need

SB Drug Discovery’s range of functionally validated potassium channel cell lines and assays enhance your understanding of compound potency and selectivity. Tailored to your research objectives, our customized assays are supported by our expert team, enabling high-throughput screening, selectivity profiling and lead optimization studies.

Voltage-Gated Channels
Kv1.1	Kv2.2	Kv7.1/minK
Kv1.2	Kv3.1	Kv7.2
Kv1.3	Kv3.2	Kv7.2 (W236L)
Kv1.4	Kv3.3	Kv7.2/7.3
Kv1.5	Kv3.4	Kv7.4
Kv1.6	Kv4.3	Kv7.4/7.5
Kv1.7	Kv4.3/kChIP	Kv7.5
Kv1.8	Kv7.1	Kv11.1 (hERG)

K₂P Channels
TREK-1 (human, mouse, rat)	TASK-3 (human and rat)	TWIK-2
TREK-2 (human, mouse, rat)	TRESK	THIK-1
TASK-1	TRAAK
TASK-2	TWIK-1

Inward Rectifiers
Kir2.1	Kir2.4	Kir4.1/5.1
Kir2.2	Kir4.1

Calcium Activated
KCa1.1 (BK)	KCa2.2 (SK2)	KCa3.1 (SK4)
KCa2.1 (SK1)	KCa2.3 (SK3)	KCa4.1 (SLACK)

Flexible assay formats

SB Drug Discovery offers an array of assay solutions for potassium channel research, employing fluorescence-based and electrophysiology assays. These versatile assays can be customized to meet specific requirements, facilitating the exploration of activators, inhibitors, and modulators essential for advancing innovative potassium channel therapeutics.

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Potassium Channel Electrophysiology

Figure 1: Representative Kv1.7 current traces before (grey line) and during the presence of increasing concentrations of the blocker Quinidine (blue lines). Currents are obtained using voltage protocol consisting of a pulse from -80 mV tp +40 mV over 200 ms.