High-throughput, label-free functional profiling with SSME technology
The human peptide transporter 1 (hPepT1 / SLC15A1) plays a critical role in intestinal absorption of di- and tri-peptides, peptide-based drugs and prodrugs such as cephalosporins, ACE inhibitors and valacyclovir. With broad substrate specificity and high expression in the gut, PepT1 is increasingly explored as a target for drug delivery, absorption and therapeutic intervention across antiviral, anticancer and metabolic disease applications.
PepT1 Assay Platform
Sygnature Discovery’s robust PepT1 transporter assays utilizing solid-supported membrane electrophysiology 9SSME) on the SURFE2R 96SE platform delivers precise, reproducible, label-free functional data to support:
- Hit identification and screening
- Kinetic profiling
- pH-dependent transporter characterisation
- Mechanistic analysis of inhibitors and substrates
Our PepT1 assays couples high-throughput performance with sensitive detection of low-turnover transporter activity, providing the resolution and reliability needed to accelerate early drug discovery.
