Ion Channel Drug Discovery

Driving Ion Channel Drug Discovery Research

At Sygnature Discovery, we recognize the diverse and complex ion channel research needs of our clients. To address this, we offer a flexible and innovative range of drug discovery solutions, utilizing the latest ion channel technologies and a comprehensive portfolio of electrophysiology assays , we are equipped to provide the necessary tools and expertise to support your ion channel drug discovery.

With our dedicated team and end-to-end ion channel screening capabilities, we deliver the results you need to advance your ion channel drug discovery research. Our services cover all aspects of ion channel screening, providing a convenient and consolidated solution to your research needs.

Access to the ion channel targets you need

Sygnature Discovery has successfully designed, generated, and validated over 150 recombinant ion channel cell lines. This extensive portfolio provides a wide range of options for your ion channel research, from high-throughput screening to off-target selectivity. Additionally, our optimized electrophysiology assays allow for efficient transition from ion channel screening to lead optimization. Throughout your research journey, you will have a single point of contact, ensuring a seamless and efficient service.

Discover tailored solutions with Sygnature Discovery, expertly adapted to your unique needs

We recognize that our clients have varied and intricate ion channel research requirements. That is why we offer a flexible and innovative range of drug discovery solutions that include an extensive collection of ion channel screening and electrophysiology assays as well as customizable cell line generation capabilities, utilizing state-of-the-art technologies.

End-to-end ion channel screening services

Target
Development

Expression validation
Cell line generation
Assay development

High-Throughput
Screening

96/384-well format
Fluorescence assays
Automated electrophysiology

HIT Verification/
lead optimization

Dose-response studies
Routine screening
Selectivity profiling

Leading technologies for rapid, reliable results

Fluorescence-Based Screening

We provide high-throughput ion channel screening using 384- and 1536-well formats. Our platforms support a wide range of assay endpoints, including calcium flux, membrane potential and thallium flux, across an extensive panel of validated targets to enable efficient, flexible screening campaigns.

Electrophysiology Studies

Our 384-well automated patch clamp electrophysiology platforms support high-throughput screening and lead optimization profiling. These include solid-supported membrane-based systems, enabling efficient and scalable electrophysiology across a wide range of ion channel targets.

Manual Patch Electrophysiology

To complement our high-throughput screening and automated electrophysiology services, we employ classical manual and two-electrode voltage clamp techniques. These methods support mechanistic studies, channel characterization and heterometic subunit investigations for complex ion channel systems.

Explore Our Approach to Ion Channel Drug Discovery

Ion channels are among the most complex and commerically important targets in drug discovery. This free eBook brings together over 20 years of Sygnature Discovery’s experience supporting even the most challenging programs.

Explore how we combine custom cell-based assay development, specialist electrophysiology platforms, and fully integrated discovery support – including DMPK, in vivo pharmacology, and protein sciences – to help you progress from hit to lead with confidence.

download the ebook